Fecal pharmaceutical research and development of future weight loss therapy

Fecal pharmaceutical research and development of future weight loss therapy

Researchers at the Brigham and Women`s hospital conducted a first trial of fecal transplants in obese patients, which showed that fecal medicine could be used as a future weight loss therapy.

According to the Boston Journal, earlier research has shown that human feces can determine health status, such as whether the bowel function is normal or whether the diet is suitable. Feces can also be transferred from healthy donors to patients with intestinal diseases to restore a delicate balance of bacteria in the gut. Researchers at the Brigham and Women's Hospital want to explore whether this treatment is suitable for helping obese patients lose weight.

Intestinal fecal transplantation is usually performed by colonoscopy, and for obesity, the researchers put the fecal material of healthy weight people into capsules, called fecal microbiota transplantation (FMT).

A total of 22 obese patients with no other health problems participated in the 12-week study. Half of the participants took the capsule and the other half took the same placebo capsule.

Through this study, the researchers hope to know if these fecal capsules have any effect on the intestinal bacterial composition of the user and whether it can cause weight loss. They focused on whether there is a change in the gut hormone called glucagon-like 1; this hormone is responsible for feeling full and associated with weight gain and loss.

At the end of the study, although significant changes in the satiety hormones were observed and there was no significant weight loss, there was sufficient evidence that the capsules altered the patient's gut flora. Specifically, the capsule group was reduced in specific bile acids compared to the placebo group, and the stool samples were closer to healthy weight donors.

Fecal pharmaceutical research and development of future weight loss therapy

Researchers are preparing additional studies to look at marketing changes in different components and components of feces. Their animal experiments found that weight loss is one of the by-products of fecal transplantation.

The study's author, Jessica Allegretti, said that in hospitals, they encountered a patient who had no other illness, but could not lose weight. This is a group of people they want to pay attention to and assist. She said the study opened a new phase in trying to understand the role of the gut microbiota in the metabolically healthy obese population, hoping to contribute to targeted treatment in the future.

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